making sense of life one phylogeny at a time
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About

Bryan Wee

Core Scientist
The Roslin Institute
The University of Edinburgh

Bryan is a core scientist at the Roslin Institute working with Chancellor’s Fellow Dr. Adrian Muwonge in the Digital One Health Laboratory. Bryan uses bioinformatic and data analysis techniques on biological and genomic sequence data to understand the evolution of pathogenicity and antibiotic resistance in bacteria.

Bryan grew up in the Malaysian Borneo state of Sarawak and currently lives in Edinburgh, Scotland.

Research

My research focus

Microbiology

I study a diverse range of pathogenic bacteria and investigate how they can exchange genetic material to speed up the evolution of traits such as virulence and antibiotic resistance. I have researched multi-drug resistant Escherichia coli, Legionella, Staphylococci, Chlamydia and Pseudomonas in addition to the microbiome, which are complex communities of bacteria.

Genomics

I apply genome sequencing to perform comparative analyses on large datasets of bacterial isolates. These data are generated using short-read Illumina technology or long-read Nanopore sequencing.

Epidemiology

Genomics provides the highest level of resolution in determining the relationships of cases in an outbreak. Understanding infection networks can help to inform rapid infection control. Genomic epidemiology can also reveal the patterns of genetic exchange between bacteria, to help understand microbial community interactions and environmental selection pressures.

A full list of my publications can be found on Google Scholar

C.V.

My curriculum vitae

  • 2005 - 2008

    Universiti Kebangsaan Malaysia

    Bachelor of Science (SmSn), majoring in Zoology
    from Universiti Kebangsaan Malaysia
    (The National University of Malaysia)

  • 2009 - 2015

    University of Queensland

    Masters of Molecular Biology
    PhD in Microbial Genomics

  • 2014 - 2016

    Queensland University of Technology

    Bioinformatician - human microbiome and fertility
    Chlamydia genomics and epidemiology

  • 2016 - 2018

    The Roslin Institute
    University of Edinburgh

    Postdoctoral Research Fellow
    Genomic epidemiology of Legionnaires' disease in Scotland

  • 2018 - 2022

    University of Edinburgh

    Postdoctoral Research Fellow
    Genomic epidemiology of antimicrobial resistance in complex systems

  • 2022 - present

    The Roslin Institute
    University of Edinburgh

    Core Scientist
    Digital One Health

  • Full
    CV
    here